UFC 261: Usman vs. Masvidal is a mixed martial arts event produced by the Ultimate Fighting Championship that will take place on April 24, 2021 at the VyStar Veterans Memorial Arena in Jacksonville, Florida, United States.
| Weight Class | Fight Card |
| Welterweight | Kamaru Usman vs. Jorge Masvidal |
| Women's Strawweight | Weili Zhang vs. Rose Namajunas |
| Women's Flyweight | Valentina Shevchenko vs. Jessica Andrade |
| Middleweight | Uriah Hall vs. Chris Weidman |
| Light Heavyweight | Anthony Smith vs. Jim Crute |
| Weight Class | Fight Card |
| Welterweight | Alex Oliveira vs. Randy Brown |
| Middleweight | Karl Roberson vs. Brendan Allen |
| Bantamweight | Danaa Batgerel vs. Kevin Natividad |
| Flyweight | Qileng Aori vs. Jeff Molina |
| Bantamweight | Jamey Simmons vs. Johnny Muñoz |
| Lightweight | Rodrigo Vargas vs. Zhu Rong |
| Welterweight | Dwight Grant vs. Stefan Sekulic |
| Women Strawweight | Liang Na vs. Ariane Carnelossi |
