UFC Vegas 21: Edwards vs Muhammad is a mixed martial arts event produced by the Ultimate Fighting Championship that will take place on March 13, 2021 at the UFC APEX, Las Vegas United States.
| Weight Class | Fight Card | Method | Round | Results |
| Welterweight | Leon Edwards vs. Belal Muhammad | Decision | R2 00:18 | Draw |
| Light Heavyweight | Misha Cirkunov vs. Ryan Spann | KO/TKO | R1 01:11 | Ryan Spann def. Misha Cirkunov |
| Featherweight | Dan Ige vs. Gavin Tucker | KO/TKO | R1 00:22 | Dan Ige def. Gavin Tucker |
| Bantamweight | Jonathan Martinez vs. Davey Grant | KO/TKO | R2 03:03 | Davey Grant def. Jonathan Martinez |
| Flyweight | Manel Kape vs. Matheus Nicolau | Decision | R3 05:00 | Matheus Nicolau def. Manel Kape |
| Middleweight | Eryk Anders vs. Darren Stewart | Decision | R1 04:37 | Draw |
| Weight Class | Fight Card | Method | Round | Results |
| Women Strawweight | Angela Hill vs. Ashley Yoder | Decision | R3 05:00 | Angela Hill def. Ashley Yoder |
| Featherweight | Charles Jourdain vs. Marcelo Rojo | KO/TKO | R3 04:31 | Charles Jourdain def. Marcelo Rojo |
| Bantamweight | Rani Yahya vs. Ray Rodriguez | Submission | R2 03:09 | Rani Yahya def. Ray Rodriguez |
| Lightweight | Nasrat Haqparast vs. Rafa Garcia | Decision | R3 05:00 | Nasrat Haqparast def. Rafa Garcia |
| Women Flyweight | Cortney Casey vs. JJ Aldrich | Decision | R3 05:00 | JJ Aldrich def. Cortney Casey |
| Women Strawweight | Gloria de Paula vs. Jinh Yu Frey | Decision | R3 05:00 | Jinh Yu Frey def. Gloria de Paula |
| Welterweight | Matthew Semelsberger vs. Jason Witt | KO/TKO | R1 00:16 | Matthew Semelsberger def. Jason Witt |
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