UFC Vegas 22: Brunson vs Holland was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on March 20, 2021 at the UFC APEX, Las Vegas United States.
UFC Vegas 22 Fight Card and Results
Main Fight Card
| Weight Class | Fight Card | Method | Round | Results |
| Middleweight | Derek Brunson vs Kevin Holland | Decision | R5 (05:00) | Derek Brunson def. Kevin Holland |
| Heavyweight | Tai Tuivasa vs Harry Hunsucker | KO/TKO | R1 (00:49) | Tai Tuivasa def. Harry Hunsucker |
| Welterweight | Kenan Song vs Max Griffin | KO/TKO | R1 (02:20) | Max Griffin def. Kenan Song |
| Women Strawweight | Cheyanne Buys vs Montserrat Ruiz | Decision | R3 (05:00) | Montserrat Ruiz def. Cheyanne Buys |
| Bantamweight | Adrian Yanez vs Gustavo Lopez | KO/TKO | R3 (00:27) | Adrian Yanez def. Gustavo Lopez |
Preliminary Fight Card
| Weight Class | Fight Card | Method | Round | Results |
| Women Bantamweight | Marion Reneau vs Macy Chiasson | Decision | R3 (05:00) | Macy Chiasson def. Marion Reneau |
| Lightweight | Leonardo Santos vs Grant Dawson | KO/TKO | R3 (04:59) | Grant Dawson def. Leonardo Santos |
| Middleweight | Trevin Giles vs Roman Dolidze | Decision | R3 (05:00) | Trevin Giles def. Roman Dolidze |
| Bantamweight | Montel Jackson vs Jesse Strader | KO/TKO | R1 (01:58) | Montel Jackson def. Jesse Strader |
| Flyweight | Bruno Silva vs JP Buys | KO/TKO | R2 (02:56) | Bruno Silva def. JP Buys |
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