Cardinals vs. 49ers: Injury report and starting lineup - October 10 | NFL Season 2021-22

In Week 5, the undefeated Arizona Cardinals face off against Trey Lance (yes, you read that correctly) and the San Francisco 49ers. The Cardinals are looking to extend their streak as the only unbeaten team in the league.

Meanwhile, thanks to the injury to quarterback Jimmy Garoppolo, rookie and third overall pick in the 2021 NFL Draft, Trey Lance takes the reins as the quarterback for Sunday's game.

Can the rookie make an immediate name for himself by defeating the Cardinals? One of the keys will be who is playing and who's not.

With that said, let's take a look at the injury report and starting lineup for both teams.

Arizona Cardinals vs. San Francisco 49ers injury report

Cardinals

The official injury report for the Arizona Cardinals shows that there are two players designated to be out for the NFC West matchup vs. the San Francisco 49ers. Those players include cornerback Byron Murphy (ribs) and offensive lineman Justin Murray (back).

Player	Position	Injury	Thursday	Friday	Game Status
Kelvin Beachum	OL	Ribs	LP	LP	Questionable
Byron Murphy, Jr.	CB	Ribs	DNP	DNP	Out
Chase Edmonds	RB	Shoulder	DNP	LP	Questionable
James Connor	RB	NIR-personal	-	-	-
Antonio Hamilton	CB	Ankle	LP	LP	Questionable
Rodney Hudson	OL	NIR-Rest	-	-	-
Chandler Jones	OLB	NIR-Rest	-	-	-
DeAndre Hopkins	WR	NIR-Rest	-	-	-
Maxx Williams	TE	Shoulder	LP	LP	Questionable
Justin Pugh	OL	Hip	LP	FP	-
Justin Murray	OL	Back	DNP	DNP	Out
Eno Benjamin	RB	Hamstring	LP	LP	Questionable
A.J. Green	WR	NIR-Rest	-	-	-
Dennis Gardeck	OLB	Hand	FP	FP	-
Marco Wilson	CB	Ribs	LP	DNP	Questionable
Corey Peters	DT	NIR-Rest	-	-	Questionable

Player Status

LP - Limited Participation

FP - Full Participation

DNP - Did Not Participate

(-) Not Listed

49ers

The injury report for the San Francisco 49ers shows that Jimmy Garoppolo is indeed an official scratch for the game, which means Trey Lance will get his very first start in the NFL.

Cornerback K'Waun Williams will also miss the game due to a calf injury.

Player	Position	Injury	Thursday	Friday	Game Status
Samson Ebukam	DL	Hamstring	DNP	LP	Questionable
Jimmy Garoppolo	QB	Calf	DNP	DNP	Out
George Kittle	TE	Calf	DNP	DNP	Doubtful
Alex Mack	C	NIR	FP	FP	-
K'Waun Williams	CB	Calf	DNP	DNP	Out
Trent Williams	T	Shoulder	FP	FP	-
Javon Kinlaw	DT	Knee	LP	LP	Questionable
Elijah Mitchell	RB	Shoulder	LP	FP	-
Josh Norman	CB	Chest	LP	FP	-
Arik Armstead	DL	NIR	DNP	FP	-
D.J. Jones	DL	NIR	DNP	FP	-

Player Status

LP - Limited Participation

FP - Full Participation

DNP - Did Not Participate

(-) Not Listed

Arizona Cardinals vs. San Francisco 49ers starting lineup

Cardinals

QB - Kyler Murray | HB - Chase Edmonds | WR - DeAndre Hopkins, A.J. Green, Christian Kirk | TE - Maxx Williams | OL - D.J. Humphries, Justin Pugh, Rodney Hudson, Kelvin Beachum, Josh Jones

DL - J.J. Watt, Rashard Lawrence, Zach Allen | LB - Jordan Hicks, Isaiah Simmons, Markus Golden, Chandler Jones | CB - Robert Alford, Antonio Hamilton | S - Jalen Thompson, Budda Baker | K - Matt Prater | P - Andy Lee

49ers

QB - Trey Lance | HB - Elijah Mitchell | FB - Kyle Juszczyk | WR - Deebo Samuel, Brandon Aiyuk, Mohamed Sanu | TE - George Kittle | OL - Trent Williams, Laken Tomlinson, Alex Mack, Daniel Brunskill, Mike McGlinchey

DL - Arik Armstead, Nick Bosa, Javon Kinlaw, D.J. Jones | LB - Marcell Harris, Fred Warner, Azeez Al-Shaair | CB - Deommodore Lenoir, Emmanuel Moseley | S - Jaquiski Tartt, Jimmie Ward | K - Joey Slye | P - Mitch Wishnowsky