NFL Week 3 Prediction, Odds, Picks and SpreadsEntering Week 3 of the 2021 NFL season, there have been several spread upsets througho the first two weeks. Jameis Winston and Mac Jones are both playing much better than anticipated. The Denver Broncos and Arizona Cardinals are both looking like legit contenders early in the season. Week 3 begins tomorrow with Thursday Night Football and here's a guide for fans who want an edge in betting on the games.NFL Thursday Night Football - Carolina Panthers at Houston TexansAdam Schefter@AdamSchefterTexans’ rookie QB Davis Mills will start Thursday night vs. Panthers. Tyrod Taylor officially ruled out.11:34 AM · Sep 21, 20214593387Texans’ rookie QB Davis Mills will start Thursday night vs. Panthers. Tyrod Taylor officially ruled out.Spread - Carolina Panthers -7.5Money Line - Carolina Panthers -405, Houston Texans +320Over/Under - 43.5Additional Prop Bet Pick - QB Davis Mills to have 1+ passing TDs in each half of his first NFL start +310Game Picks - Houston Texans +7.5 to cover the spread, Carolina Panthers to win (-405), over 43.5 points (-104)Game Prediction - Carolina Panthers 26 - Houston Texans 20Arizona Cardinals at Jacksonville JaguarsJohnny Venerable@JohnnyVenerableThrough two weeks to begin the season, the Arizona Cardinals are second in total offense (445) and total points scored (72).These outputs came against two defensive head coaches.Next up, the 0-2 Jacksonville Jaguars. #PHNX #AZCardinals1:59 AM · Sep 21, 20212976Through two weeks to begin the season, the Arizona Cardinals are second in total offense (445) and total points scored (72).These outputs came against two defensive head coaches.Next up, the 0-2 Jacksonville Jaguars. #PHNX #AZCardinals https://t.co/JuU76RBJ9USpread - Arizona Cardinals -7.5Money Line - Arizona Cardinals -360, Jacksonville Jaguars +290Over/Under - 51.5Additional Prop Bet Pick - Line/Total Points Parlay - Arizona Cardinals to win by at least eight points and the game having under 51.5 points scored +280Game Picks - Arizona Cardinals -7.5 to cover the spread and win the game, under 51.5 points (-105)Game Prediction - Arizona Cardinals 30 - Jacksonville Jaguars 19Indianapolis Colts at Tennessee TitansJ. Guzman@TheJoezillaAJ Brown vs the Colts 11 catches for 189 yards and 2 touchdowns (4 games )Julio Jones vs the Colts 20 catches for 419 yards and 3 touchdowns (3 games)#Titans #INDvsTEN7:11 AM · Sep 22, 2021AJ Brown vs the Colts 11 catches for 189 yards and 2 touchdowns (4 games )Julio Jones vs the Colts 20 catches for 419 yards and 3 touchdowns (3 games)#Titans #INDvsTEN https://t.co/xSieLQ5D0HSpread - Tennessee Titans -5.5Money Line - Indianapolis Colts +205, Tennessee Titans -250Over/Under - 48.5Additional Prop Bet Pick - Team to score first and win - Indianapolis Colts +320Game Picks - Indianapolis Colts +5.5 to win, over 48.5 points (-105)Game Prediction - Indianapolis Colts 28 - Tennessee Titans - 24Baltimore Ravens at Detroit LionsKevin Oestreicher@koestreicher34In honor of it being Lions week for the Ravens, here’s a video of Justin Tucker nailing a 61-yard field goal to give Baltimore an 18-16 win over Detroit almost 8 years ago6:01 AM · Sep 21, 20212742359In honor of it being Lions week for the Ravens, here’s a video of Justin Tucker nailing a 61-yard field goal to give Baltimore an 18-16 win over Detroit almost 8 years ago https://t.co/XF8BvwgdJOSpread - Baltimore Ravens -7.5Money Line - Baltimore Ravens -450, Detroit Lions +350Over/Under - 49.5Additional Prop Bet Pick -1st Drive Results - Field Goal Attempt +420Game Picks - Baltimore Ravens -7.5 to cover the spread and win the game, under 49.5 points (-106)Game Prediction - Baltimore Ravens 23 - Detroit Lions 13Washington Football Team at Buffalo BillsBuffalo Bills@BuffaloBillsWashington Week is HERE!We’re LIVE with Coach McDermott before practice at One Bills Drive.#WSHvsBUF | #BillsMafia twitter.com/i/broadcasts/1…12:03 PM · Sep 22, 202112414Washington Week is HERE!We’re LIVE with Coach McDermott before practice at One Bills Drive.#WSHvsBUF | #BillsMafia twitter.com/i/broadcasts/1…Spread - Buffalo Bills -7.5Money Line - Washington +270, Buffalo Bills -335Over/Under - 45.5Additional Prop Bet Pick - Double Result - Washington Football Team to lead at halftime, Buffalo Bills to win the game +650Game Picks - Buffalo Bills -7.5 to win but not cover the spread, over 45.5 points (-110)Game Prediction - Washington Football Team 20 - Buffalo Bills 26New Orleans Saints at New England PatriotsMike Reiss@MikeReiss“If you were trying to build a perfect back, he essentially has everything you need.” — Patriots LB Dont’a Hightower, on Saints RB Alvin Kamara11:05 AM · Sep 22, 202170552“If you were trying to build a perfect back, he essentially has everything you need.” — Patriots LB Dont’a Hightower, on Saints RB Alvin Kamara https://t.co/nE8oC2AQCDSpread - New England Patriots -3Money Line - New Orleans Saints +126, New England Patriots -146Over/Under - 41.5Additional Prop Bet Pick - Any Time Touchdown Scorer - Chris Hogan +750Game Picks - New England Patriots -3 to cover the spread and win the game, over 41.5 points (-115)Game Prediction - New Orleans Saints 21 - New England Patriots 26LA Chargers at Kansas City ChiefsField Yates@FieldYatesThrough 17 career starts, Patrick Mahomes and Justin Herbert have more passing yards than any other players in NFL history. Chiefs vs. Chargers on Sunday.10:47 AM · Sep 22, 20212366236Through 17 career starts, Patrick Mahomes and Justin Herbert have more passing yards than any other players in NFL history. Chiefs vs. Chargers on Sunday. https://t.co/uls8EqwsvfSpread - Kansas City Chiefs -6.5Money Line - LA Chargers +250, Kansas City Chiefs -310Over/Under - 55.5Additional Prop Bet Pick - First Touchdown Scorer - Travis Kelce +600Game Picks - Kansas City Chiefs -6.5 to cover the spread and win, under 55.5 points (-114)Game Prediction - LA Chargers 16 - Kansas City Chiefs 26Chicago Bears at Cleveland BrownsChicago Bears@ChicagoBearsCoach Nagy has announced that Justin Fields will be our starting QB against the Browns.12:52 PM · Sep 22, 2021226813934Coach Nagy has announced that Justin Fields will be our starting QB against the Browns.Spread - Cleveland Browns -7.5Money Line - Chicago Bears +260, Cleveland Browns -320Over/Under - 46.5Additional Prop Bet Pick - Both teams to score 1+ TD in each half - yes +196Game Picks - Cleveland Browns -7.5 to cover the spread and win, over 46.5 points (-105)Game Prediction - Chicago Bears 20 - Cleveland Browns 28Cincinnati Bengals at Pittsburgh SteelersChristopher Carter@CarterCritiquesJoe Schobert with what #Steelers are looking at #Bengals offense, talking about Joe and Joe being the offense (Burrow/Mixon) and how the run game has made up for less mobility from Burrow:2:40 AM · Sep 22, 202161Joe Schobert with what #Steelers are looking at #Bengals offense, talking about Joe and Joe being the offense (Burrow/Mixon) and how the run game has made up for less mobility from Burrow: https://t.co/Rwy4A67HsoSpread - Pittsburgh Steelers -3Money Line - Cincinnati Bengals +144, Pittsburgh Steelers -172Over/Under - 43.5Additional Prop Bet Pick - Line/Total Points Parlay - Pittsburgh Steelers -3 to cover the spread and win with over 44.5 points scored +340Game Picks - Pittsburgh Steelers -3 to cover the spread and win, over 44.5 points (-110)Game Predicition - Cincinnati Bengals 21 - Pittsburgh Steelers 27Atlanta Falcons at New York GiantsIan Rapoport@RapSheet#Falcons WR Russell Gage is considered week-to-week with an ankle injury suffered on Sunday, source said. The team will see on Friday if he can possibly go this week vs the #Giants, though it appears as a bit of a long-shot at first glance.11:35 AM · Sep 22, 2021661104#Falcons WR Russell Gage is considered week-to-week with an ankle injury suffered on Sunday, source said. The team will see on Friday if he can possibly go this week vs the #Giants, though it appears as a bit of a long-shot at first glance.Spread - New York Giants -3Money Line - Atlanta Falcons +134, New York Giants -158Over/Under - 47.5Additional Prop Bet Pick - Total 1st Half points - over 23.5 +100Game Picks - Atlanta Falcons +3 to win, under 47.5 points (-112)Game Prediction - Atlanta Falcons 20 - New York Giants 17Miami Dolphins at Las Vegas RaidersAdam Schefter@AdamSchefterWith Tua Tagovailoa out Sunday vs. the Raiders, Jacoby Brissett will start for the Dolphins and Reid Sinnett will backup. twitter.com/adamschefter/s…Adam Schefter@AdamSchefterTua Tagovailoa has fractured ribs and is out Sunday.11:27 AM · Sep 22, 20211617234Tua Tagovailoa has fractured ribs and is out Sunday.1:49 AM · Oct 11, 2018With Tua Tagovailoa out Sunday vs. the Raiders, Jacoby Brissett will start for the Dolphins and Reid Sinnett will backup. twitter.com/adamschefter/s…Spread - Las Vegas Raiders -3.5Money Line - Miami Dolphins +168, Las Vegas Raiders -200Over/Under - 45.5Additional Prop Bet Pick - Josh Jacobs over 71.5 rushing yards (-105)Game Picks - Las Vegas Raiders -3.5 to cover the spread and win, over 45.5 points (-105)Game Prediction - Miami Dolphins 17 - Las Vegas Raiders 30New York Jets at Denver BroncosAric DiLalla@AricDiLallaVic Fangio on the home opener against the Jets, with the Broncos sitting at 2-0:“I expect an electric stadium.”4:30 AM · Sep 19, 202149236Vic Fangio on the home opener against the Jets, with the Broncos sitting at 2-0:“I expect an electric stadium.”Spread - Denver Broncos -10.5Money Line - New York Jets +450, Denver Broncos -600Over/Under - 41.5Additional Prop Bet Pick - Denver Broncos to score in every quarter - Yes +130Game Picks - Denver Broncos -10.5 win, but doesn't cover the spread, over 41.5 points (-105)Game Prediction - New York Jets 21 - Denver Broncos 26Tampa Bay Buccaneers at LA RamsAdam Schefter@AdamSchefterWhen the Buccaneers play at the Rams on Sunday, it will mark the first NFL game that Tom Brady has played in Los Angeles.7:16 AM · Sep 20, 2021221271136When the Buccaneers play at the Rams on Sunday, it will mark the first NFL game that Tom Brady has played in Los Angeles.Spread - Tampa Bay Buccaneers -1.5Money Line - Tampa Bay Buccaneers -122, LA Rams +104Over/Under - 55.5Additional Prop Bet Pick - Matthew Stafford throwing over 299.5 yards -114Game Picks - LA Rams +1.5 win, under 55.5 points (-110)Game Prediction - Tampa Bay Buccaneers 24 - LA Rams 29Seattle Seahawks at Minnesota VikingsAli Siddiqui@asiddiqui15#vikings last win against the Seahawks came in 2009.Brett Favre threw 4 TDs.6:11 AM · Sep 21, 20214#vikings last win against the Seahawks came in 2009.Brett Favre threw 4 TDs. https://t.co/8q6i9ZlpCWSpread - Seattle Seahawks -1.5Money Line - Seattle Seahawks -120, Minnesota Vikings +102Over/Under - 55.5Additional Prop Bet Pick - Lowest Scoring Quarter - Second +700Game Picks - Seattle Seahawks -1.5 cover the spread and win, under 55.5 points (-110)Game Prediction - Seattle Seahawks 27 - Minnesota Vikings 23NFL Sunday Night Football - Green Bay Packers at San Francisco 49ersOurSF49ers@OurSf49ers_It’s Packers week! 🧀 Throwback to the 2012 NFC Divisional Playoff Game 🔥🔥 #49ers || #FTTB12:02 PM · Sep 21, 20212730479It’s Packers week! 🧀 Throwback to the 2012 NFC Divisional Playoff Game 🔥🔥 #49ers || #FTTB https://t.co/7589iikM64Spread - San Francisco 49ers -3.5Money Line - Green Bay Packers +154, San Francisco 49ers -184Over/Under - 49.5Additional Prop Bet Pick - George Kittle over 56.5 receiving yards -114Game Picks - San Francisco 49ers -3.5 cover the spread and win, under 49.5 points (-105)Game Prediction - Green Bay Packers 20 - San Francisco 49ers 26NFL Monday Night Football - Philadelphia Eagles at Dallas CowboysRJ Ochoa@rjochoaTrevon Diggs has never not had an interception during a game against the Philadelphia Eagles.Trevon Diggs has had an interception in every game this season.The Cowboys host Philly on Monday Night Football.3:23 AM · Sep 22, 202159038Trevon Diggs has never not had an interception during a game against the Philadelphia Eagles.Trevon Diggs has had an interception in every game this season.The Cowboys host Philly on Monday Night Football.Spread - Dallas Cowboys -3.5Money Line - Philadelphia Eagles +160, Dallas Cowboys -190Over/Under - 51.5Additional Prop Bet Pick - Dallas Cowboys -4.5 to win and under 51.5 points scored in the game +300Game Picks - Philadelphia Eagles 21 - Dallas Cowboys 27Also Check Out: Complete NFL Week 3 TV Schedule