San Francisco 49ers vs. Tampa Bay Buccaneers projected starting lineup and depth chart for Week 6 | 2025 NFL season

The San Francisco 49ers (4-1) will lock horns with the Tampa Bay Buccaneers (4-1) in Week 6 of the 2025 NFL season on Sunday. The game will kick off at 4:25 p.m. ET from Raymond James Stadium in Tampa, Florida.

Ahead of the 49ers vs. Buccaneers game, here's a look at the projected lineups for both teams.

San Francisco 49ers vs. Tampa Bay Buccaneers projected starting lineup for Week 6

San Francisco 49ers projected starting lineup

NFL: San Francisco 49ers RB Christian McCaffrey - Source: Imagn

Here's a look at the 49ers' projected starters on offense vs. the Buccaneers:

Position	Starter
QB	Mac Jones
RB	Christian McCaffrey
WR (X)	Jauan Jennings
WR (Z)	Skyy Moore
WR (SL)	Kendrick Bourne
TE	Jake Tonges
FB	Kyle Juszczyk
LT	Trent Williams
LG	Connor Colby
C	Jake Brendel
RG	Dominick Puni
RT	Colton McKivitz

Here's a look at the 49ers' projected starters on defense vs. the Buccaneers:

Position	Starter
LDE	Bryce Huff
LDT	Kalia Davis
RDT	Jordan Elliott
RDE	Mykel Williams
WLB	Dee Winters
MLB	Fred Warner
SLB	Luke Gifford
LCB	Renardo Green
SS	Marques Sigle
FS	Jason Pinnock
RCB	Deommodore Lenoir
NB	Upton Stout

Here's a look at the 49ers' projected starters on special teams vs. the Buccaneers:

Position	Starter
PK	Eddy Pineiro
P	Thomas Morstead
H	Thomas Morstead
PR	Skyy Moore
KR	Isaac Guerendo
LS	Jon Weeks

Tampa Bay Buccaneers projected starting lineup

Tampa Bay Buccaneers QB Baker Mayfield - NFL 2025 - Source: Getty

Here's a look at the Buccaneers' projected starters on offense vs. the 49ers:

Position	Starter
QB	Baker Mayfield
RB	Rachaad White
WR (X)	Sterling Shepard
WR (Z)	Tez Johnson
WR (SL)	Emeka Egbuka
TE	Cade Otton
LT	Tristan Wirfs
LG	Ben Bredeson
C	Graham Barton
RG	Luke Haggard
RT	Charlie Heck

Here's a look at the Buccaneers' projected starters on defense vs. the 49ers:

Position	Starter
LDE	Elijah Roberts
NT	Vita Vea
RDE	Logan Hall
WLB	Yaya Diaby
LILB	SirVocea Dennis
RILB	Lavonte David
SLB	Haason Reddick
LCB	Jamel Dean
SS	Antoine Winfield Jr.
FS	Tykee Smith
RCB	Josh Hayes
NB	Jacob Parrish

Here's a look at the Buccaneers' projected starters on special teams vs. the 49ers:

Position	Starter
PK	Chase McLaughlin
P	Riley Dixon
H	Riley Dixon
PR	Kameron Johnson
KR	Sean Tucker
LS	Evan Deckers

San Francisco 49ers vs. Tampa Bay Buccaneers depth chart for Week 6

San Francisco 49ers depth chart

Here's a look at the 49ers' depth chart for their offense:

Position	Starter	2nd	3rd	4th
QB	Brock Purdy (O)	Mac Jones (Q)	Adrian Martinez	Kurtis Rourke (O)
RB	Christian McCaffrey	Brian Robinson Jr.	Isaac Guerendo	Jordan James
WR (X)	Jauan Jennings (Q)	Demarcus Robinson	Jordan Watkins (O)	Trent Taylor (IR)
WR (Z)	Ricky Pearsall (O)	Skyy Moore	Brandon Aiyuk (O)	–
WR (SL)	Kendrick Bourne	Marquez Valdes-Scantling	Jacob Cowing (IR)	–
TE	Jake Tonges	Luke Farrell	Brayden Willis	George Kittle (IR)
FB	Kyle Juszczyk	–	–	–
LT	Trent Williams	Spencer Burford (IR)	–	–
LG	Connor Colby	Ben Bartch (IR)	–	–
C	Jake Brendel	Matt Hennessy	–	–
RG	Dominick Puni	Drew Moss	–	–
RT	Colton McKivitz	Austen Pleasants	Isaac Alarcon (SUSP)	–

Here's a look at the 49ers' depth chart for their defense:

Position	Starter	2nd	3rd	4th
LDE	Bryce Huff	Yetur Gross-Matos (O)	Tarron Jackson (IR)	–
LDT	Kalia Davis (Q)	Alfred Collins (Q)	Kevin Givens (IR)	–
RDT	Jordan Elliott	CJ West	–	–
RDE	Mykel Williams	Sam Okuayinonu	Trevis Gipson	Nick Bosa (IR)
WLB	Dee Winters	Nick Martin	–	–
MLB	Fred Warner	Tatum Bethune	–	–
SLB	Luke Gifford	Curtis Robinson	–	–
LCB	Renardo Green	Tre Tomlinson (IR)	–	–
SS	Marques Sigle	Ji’Ayir Brown	–	–
FS	Jason Pinnock	Malik Mustapha (Q)	Siran Neal	–
RCB	Deommodore Lenoir	Darrell Luter Jr.	Jakob Robinson (IR)	–
NB	Upton Stout (Q)	Chase Lucas	–	–

Here's a look at the 49ers' depth chart for their special teams:

Position	Starter	2nd	3rd	4th
PK	Eddy Pineiro	–	–	–
P	Thomas Morstead	–	–	–
H	Thomas Morstead	–	–	–
PR	Skyy Moore	Jordan Watkins (O)	Jacob Cowing (IR)	–
KR	Isaac Guerendo	Skyy Moore	–	–
LS	Jon Weeks	–	–	–

Tampa Bay Buccaneers depth chart

Here's a look at the Buccaneers' depth chart for their offense:

Position	Starter	2nd	3rd	4th
QB	Baker Mayfield	Teddy Bridgewater	–	–
RB	Bucky Irving (O)	Rachaad White	Sean Tucker	Josh Williams (O)
WR (X)	Mike Evans (O)	Sterling Shepard	Kameron Johnson	–
WR (Z)	Chris Godwin Jr. (O)	Tez Johnson	Jalen McMillan (IR)	–
WR (SL)	Emeka Egbuka	Ryan Miller	Jaden Smith (IR)	–
TE	Cade Otton	Payne Durham	Devin Culp	Ko Kieft (IR)
LT	Tristan Wirfs	Graham Barton	–	–
LG	Ben Bredeson	Elijah Klein	Mike Jordan	Dan Feeney
C	Graham Barton	Ben Bredeson	–	–
RG	Luke Haggard	Elijah Klein	Cody Mauch (IR)	–
RT	Charlie Heck	Benjamin Chukwuma	Luke Goedeke (IR)	–

Here's a look at the Buccaneers' depth chart for their defense:

Position	Starter	2nd	3rd	4th
LDE	Elijah Roberts	C.J. Brewer	Calijah Kancey (IR)	–
NT	Vita Vea	Elijah Simmons	–	–
RDE	Logan Hall	Greg Gaines	–	–
WLB	Yaya Diaby	Chris Braswell	David Walker (IR)	–
LILB	SirVocea Dennis	John Bullock	–	–
RILB	Lavonte David	Deion Jones	–	–
SLB	Haason Reddick	Anthony Nelson	Markees Watts	–
LCB	Jamel Dean	Benjamin Morrison (O)	–	–
SS	Antoine Winfield Jr.	Christian Izien (Q)	Sebastian Castro	JJ Roberts (IR)
FS	Tykee Smith	Kaevon Merriweather	Rashad Wisdom (IR)	–
RCB	Zyon McCollum (O)	Josh Hayes	–	–
NB	Jacob Parrish	Kindle Vildor	–	–

Here's a look at the Buccaneers' depth chart for their special teams:

Position	Starter	2nd	3rd	4th
PK	Chase McLaughlin	–	–	–
P	Riley Dixon	–	–	–
H	Riley Dixon	–	–	–
PR	Kameron Johnson	Rachaad White	Tez Johnson	Jalen McMillan (IR)
KR	Sean Tucker	Josh Williams (O)	Emeka Egbuka	Kameron Johnson
LS	Evan Deckers	–	–	–

How to watch the San Francisco 49ers vs. Tampa Bay Buccaneers game? TV channel and live stream details for Week 6 contest

The 49ers vs. Buccaneers Week 6 game will be broadcast live on CBS. Fans can also live stream the contest on Paramount+ or Fubo.