#1 100 vs New York Knicks, March 2nd, 1962
The Philadelphia Warriors entered this game after winning by 9 against the Chicago Packers and improved to 45-29. Wilt dropped 61 points in that game and grabbed 28 boards. A night after that, Wilt did something no one has ever done.
He exploded for 100 points on a 36-63 shooting, with a field-goal percentage of 57.1. Wilt also had 25 rebounds and 2 assists. This is one of the most prestigious records in basketball and is highly unlikely to be broken. Chamberlain played all 48-minutes of the game and committed two personal fouls. He attempted a ridiculous 32 free-throws and sank 28 of those.
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The 4-time NBA MVP scored 31 points in the fourth quarter and shot 12-21 from the field. The Warriors won the game, 169-147 because of Wilt's heroics. Only Kobe Bryant came close to breaking this record when he scored 81 points against the Chicago Bulls in 2006.