5 NBA teams LeBron James has the most regular-season losses against

#3 Indiana Pacers - 22 Losses

LeBron James #23 of the Los Angeles Lakers drives to the basket while guarded by Justin Holiday #8 of the Indiana Pacers during the fourth quarter at Bankers Life Fieldhouse on May 15, 2021 in Indianapolis, Indiana.

The Indiana Pacers are the third-ranked team on this list. LeBron has lost 22 games against the Pacers, having secured 38 wins from 60 outings.

In 38.8 minutes fielded per game, LeBron James averaged 27.1 points, 7.6 rebounds, 6.7 assists, 1.6 steals and 0.9 blocks against the Pacers. He has clocked the most amount of time on the court playing against a team (2,331 minutes) against the Pacers. The 2007-08 scoring champion has scored a total of 1,627 points against the Pacers, rebounded 455 times, and assisted 403 times, with 98 and 53 steals and blocks respectively. He also has a field goal percentage of 49.7, in 19.7 attempts made from the field per game.

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#2 Boston Celtics - 22 Losses

Jayson Tatum #0 of the Boston Celtics defends LeBron James #23 of the Los Angeles Lakers at TD Garden on January 20, 2020 in Boston, Massachusetts. The Celtics defeat the Lakers 139-107.

LeBron James' second-most regular-season losses are against the Boston Celtics, with the same number of losses as the Pacers (22) but in a lesser number of games (54). On average, he has attempted to make 20.6 shots from the field and succeeded in netting 10.3 times, giving him a field goal percentage of 50 against the Celtics.

The four-time championship ring holder has averaged 28.9 points, 7.2 rebounds, 7.1 assists, 1.6 steals and 1.0 blocks per game against the Celtics in 38.8 minutes played. LeBron James was fielded on the court for 2,093 minutes against the Celtics and recorded a total of 1,558 points, 391 rebounds, 386 assists, 88 steals and 55 blocks.

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#1 Chicago Bulls - 26 Losses

LeBron James #23 of the Cleveland Cavaliers listens to a coach during the second half against the Chicago Bulls at the United Center on March 17, 2018 in Chicago, Illinois. The Cavaliers defeated the Bulls 114-109.

There's no doubt LeBron James loves to go against the Chicago Bulls as he has recorded his second-best points against a team playing against them (1,678). However, he has lost the most games to them in an NBA regular season (26), recording his lowest win percentage (.441) against an NBA team.

The first overall pick in the 2003 NBA Draft who made his NBA debut with the Cleveland Cavaliers has an average of 28.4 points, 7.5 rebounds, 6.6 assists, 1.7 steals and 0.6 blocks per game against the Bulls. LeBron James recorded a total of 2,031 minutes (his second most time spent on the court against an NBA team). In that time, he has successfully completed a total of 445 rebounds, 388 assists, 102 steals (his second-most steals against a team) and 48 blocks.