Minnesota Timberwolves vs Portland Trail Blazers Predicted Starting Lineups and Depth Charts for Oct. 22 | 2025-26 NBA Season

The Minnesota Timberwolves and Portland Trail Blazers will cross swords in a regular-season game at the Moda Center on Wednesday. Anthony Edwards and the Wolves have unfinished business from last season. Chris Finch's team crashed out of the playoffs after getting humbled by the eventual champions, the OKC Thunder, in the Western Conference finals.

The Timberwolves are running it back with the same core from last season. Edwards is the undisputed leader and is motivated to make a run at his maiden MVP honor as well as the Larry O'Brien Trophy. The superstar point guard is expected to be in the top 3 in the MVP race.

Jaden McDaniels is Minnesota's second most important player and the team's defensive anchor, along with Rudy Gobert. Donte DiVincenzo didn't have a good year last season and will look to bounce back in style. Terrence Shannon Jr. showed flashes of brilliance last season and is expected to take a massive leap this season.

Meanwhile, the Blazers aren't expected to pose even a little threat in the stacked Western Conference. Damian Lillard is expected to miss the entire season due to a torn Achilles tendon. Portland is expected to be a lottery team this season, allowing its young core to develop and gain experience, with veteran Jrue Holiday providing leadership and guidance along the way.

Minnesota Timberwolves vs Portland Trail Blazers Injury Reports

Minnesota Timberwolves injury report

Anthony Edwards is the only player on the Timberwolves' injury report for the opening night game. The three-time All-Star is listed as questionable owing to a back spasm. An official update on his status will be known ahead of tip off.

Portland Trail Blazers injury report

Three Blazers players are ruled out of Wednesday's game. Damian Lillard remains sidelined with a left Achilles tendon injury, Scoot Henderson is dealing with a left hamstring tear and Robert Williams III is inching closer to return but still hasn't regained full fitness.

Minnesota Timberwolves vs Portland Trail Blazers Starting Lineups and Depth Charts

Minnesota Timberwolves Starting Lineup and Depth Chart

The Timberwolves' starting lineup features familiar faces. Anthony Edwards and Mike Conley Jr. in the backcourt, Jaden McDaniels and Julius Randle on the wing and Rudy Gobert in the center.

PG	SG	SF	PF	C
Mike Conley	Anthony Edwards	Jaden McDaniels	Julius Randle	Rudy Gobert
Rob Dillingham	Donte DiVincenzo	Terrence Shannon Jr.	Naz Reid	Joan Beringer
Tristen Newton		Jaylen Clark
	Johnny Juzang		Leonard Miller

Portland Trail Blazers Starting Lineup and Depth Chart

Jrue Holiday, Shaedon Sharpe, Toumani Camara, Deni Avdija and Donovan Clingan are the Blazers' starters for the opening night.

PG	SG	SF	PF	C
Jrue Holiday	Shaedon Sharpe	Deni Avdija	Toumani Camara	Donovan Clingan
Caleb Love	Rayan Rupert	Matisse Thybulle	Jerami Grant	Yang Hansen
	Blake Wesley		Kris Murray
				Duop Reath