Browns vs. Cardinals prediction, odds, and picks

The lone undefeated team in the National Football League, the Arizona Cardinals will travel to Cleveland to face the Browns this Sunday. It will be a matchup of two former University of Oklahoma quarterbacks and Heisman Trophy winners facing off. The Browns are coming off a dominant offensive game against the Chargers, where both teams had a combined 1000 yards on offense. The Browns narrowly lost the 47-42 game, falling to 3-2.

The Cardinals had a narrow victory over their divisional rival, San Francisco 49ers, last Sunday 17-10, keeping their undefeated record alive. The Cardinals made a significant trade on Friday morning, adding Philadelphia Eagles tight end Zach Ertz to the roster. Although Ertz won't be activated to play on Sunday afternoon, he gives the offense a solid option in the passing game as TE1.

Arizona Cardinals vs. Cleveland Browns

When: Sunday, October 17, 2021, at 4:05 PM EST

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Where: FirstEnergy Stadium, Cleveland, Ohio

Arizona Cardinals vs. Cleveland Browns Betting Odds

Spreads

Cardinals: +3.5 (-115)

Browns: -3.5 (-105)

Moneyline

Cardinals: +155

Browns: -180

Totals

Cardinals: o49.5(-105)

Browns: u49.5 (-115)

Arizona Cardinals vs. Cleveland Browns Picks

The Cardinals are undefeated, yet the Browns are in with a chance in this matchup. Lined up against the Cardinals' powerful defense, the quarterback Baker Mayfield's passing game may be in distress and in for a long afternoon.

Arizona Cardinals vs. Cleveland Browns Key Injuries

Cardinals

LB Jordan Hicks-toe (questionable)
WR DeAndre Hopkins-illness
QB Kyler Murray-shoulder
CB Byron Murphy-ribs (questionable)
RB Chase Edmunds-shoulder (questionable)
OL Kelvin Beachum-ribs (questionable)
LB Dennis Gardeck-hand

Browns

RB Nick Chubb-calf (OUT
DE Jadeveon Clowney-elbow/knee (questionable)
DE Myles Garrett-knee/ankle (questionable)
C J.C. Tretter-knee
TE David Njoku-knee (questionable)
T Jack Conklin-knee
RB Kareem Hunt-wrist/knee (questionable)
CB Denzel Ward-neck

Arizona Cardinals vs. Cleveland Browns Head to Head

The Cardinals and Browns have met 51 times dating back to 1950. The Browns lead the series 33-15-3. The last time both teams met was December 15, 2019, with the Arizona Cardinals earning the 38-24 victory over the Cleveland Browns.

Arizona Cardinals vs. Cleveland Browns Prediction

The Cardinals could stay undefeated this weekend by getting a narrow victory over the Browns. Cleveland has numerous injuries, mostly to their offense, that may cause for a lot of scrambling. Mayfield threw for over 300 yards against the Chargers last week, but the Cardinals defense most likely won't be allowing that many yards this week.

Prediction

The Cardinals will defeat the Browns 21-17 to remain undefeated.

About the author

Bethany Cohen is an NFL writer at Sportskeeda, with a rich prior 15-year experience in the sports writing industry, primarily covering the MLB and MiLB. She majored in Communications from the University of South Florida and has previously worked for top companies such as Examiner.com and Legends on Deck.

Bethany owes her NFL allegiance to the Pittsburgh Steelers owing to their long-standing tradition and competitiveness. She is a fan of old stalwarts such as Terry Bradshaw and Franco Harris and would love to watch them in the 1970s if she manages to get her hand on a time machine. She also acknowledges the greatness of modern icons like T.J. Watt for his desire to continuously improve despite being on top. She admires coaches Mike Tomlin and Andy Reid for their longevity and success.

The ace reporter credits her knowledge and love for the sport to be her biggest reporting strengths. Prior fact-checking is a big component of her process and she always scours through additional sources to ensure complete accuracy in her content.

Super Bowl XLIII, when the Steelers won the the grand prize after Santonio Holmes’ epic catch in the end zone with just seconds left on the clock is etched in Bethany’s memory forever. When she is free of her professional commitments, she likes to attend sports events and music concerts.

Know More

Cardinals Nation! You can check out the latest Arizona Cardinals Schedule and dive into the latest Cardinals Depth Chart for NFL Season 2024-25.

Edited by Henno van Deventer

Browns vs. Cardinals prediction, odds, and picks - October 17 | NFL season 2021-22