The Week 6 matchup between the Houston Texans and Indianapolis Colts was seen as a throw-away game a few weeks ago. Since Week 4, the Indianapolis Colts have shown signs of life on offense, while Texans quarterback Davis Mills has thrown four interceptions in one game and three touchdowns in the next.Indianapolis Colts@ColtsCan't take this one away. 🙌📺 ESPN10:22 AM · Oct 11, 20211738305Can't take this one away. 🙌📺 ESPN https://t.co/tTZhTamB4mBoth the Texans and Colts are 1-4 in the AFC South and are two games behind the Tennessee Titans. Carson Wentz seems to be at least near 100% and running back Jonathan Taylor has finally stepped up to help carry the offense. For the Texans, it falls on rookie Davis Mills and how he performs. He looked like the best rookie quarterback of Week 5 against the New England Patriots and could easily keep it close against the Colts.Texans vs Colts Predictions, Odds and PicksMatch DetailsMatch: Houston Texans at Indianapolis Colts | NFL Week 6, 2021Date & Time: Sunday, October 17th, 2021 at 1:00 PM ESTVenue: Lucas Oil Stadium, Indianapolis, IndianaTexans vs Colts Betting OddsSpreadsTexans: +10 (-110)Colts: -10 (-110)Money LineTexans: +360Colts: -460Over/Under TotalOver 43.5: -110Under 43.5: -110Texans vs Colts Game PicksThe Houston Texans are 10-point underdogs, but it depends on how rookie Davis Mills plays. Ten points is pretty high and it seems best to pick the Houston Texans to lose by less than 10 points. Take the over, as the Colts should have a great offensive outing and the Texans will keep it close.Texans vs Colts Key InjuriesColtsThe Indianapolis Colts could be without kicker Rodrigo Blankenship due to a hip injury from Monday's game. He hasn't practiced this week, but it could be for rest. Linebacker Darius Leonard (ankle/shoulder) was upgraded to limited participation on Thursday and should play on Sunday. Cornerback Xavier Rhodes suffered a concussion against the Baltimore Ravens but did have limited practice on Thursday.Ian Rapoport@RapSheetThe #Colts are working out kickers today with starter Rodrigo Blankenship suffering from a hip injury that limited him on MNF. Blankenship may miss a little time. The team is working out at least FA Ks Brett Maher and Michael Badgley, sources say. Badgley was once a UDFA in Indy.10:42 AM · Oct 13, 20211922174The #Colts are working out kickers today with starter Rodrigo Blankenship suffering from a hip injury that limited him on MNF. Blankenship may miss a little time. The team is working out at least FA Ks Brett Maher and Michael Badgley, sources say. Badgley was once a UDFA in Indy.Tackle Braden Smith (foot/thumb) and safety Andrew Sendejo (concussion) haven't practiced yet this week and seem questionable at best. Defensive ends Kwity Paye (hamstring) and Issac Rochell (illness) had full practices and will be on the field barring a setback.Brooks Kubena@BKubena#Texans running back Rex Burkhead is back at practice. He missed yesterday’s practice after returning Wednesday for the first time since his hip injury in Buffalo.12:44 PM · Oct 15, 202131#Texans running back Rex Burkhead is back at practice. He missed yesterday’s practice after returning Wednesday for the first time since his hip injury in Buffalo.TexansThe Texans are in danger of losing several key starters for Sunday's game: offensive lineman Justin Britt (knee), tackle Laremy Tunsil (thumb), and running back Rex Burkhead (hip). All three players did not practice on Thursday. Tight end Pharoah Brown (shoulder), wide receiver Danny Amendola (thigh), and cornerback Desmond King (hip) were all limited in practice and could be good for Sunday.Texans vs Colts Head-to-HeadThe Indianapolis Colts have a huge lead in their series with the Houston Texans 30-9, dating back to 2002. The Colts swept the Texans in 2020 in close games. The Texans went 1-2 against the Colts during the 2018 season, winning their first meeting in overtime and then also losing in the AFC Wild Card game 21-7.Texans vs Colts PredictionsThe Colts are heavy favorites against the Texans, who have several starters questionable for the game. Davis Mills will likely be playing from behind for most of the game, but could cover the spread and lose by less than 10 points. He threw for three touchdowns last week against the Patriots and could have a similar game.StatMuse@statmuseDavis Mills vs the Patriots:21/29311 YDS3 TD0 INT141.6 RTG4:15 AM · Oct 10, 202152552Davis Mills vs the Patriots:21/29311 YDS3 TD0 INT141.6 RTG https://t.co/Icr2H9rDH4Carson Wentz and the Colts offense are finally able to build momentum and carry it into Week 6, which should pull off a win against Houston's defense.PredictionI am taking the Indianapolis Colts to win, thanks to running-back Jonathan Taylor rushing for over 60 rushing yards, 60 receiving yards and two total touchdowns.