The Buffalo Bills ride a four-game winning streak into Nissan Stadium Monday night to face the Tennessee Titans. The Titans are 3-2 and still have a two-game lead in the AFC South.The Bills defense enters Week 6 as the best in the National Football League. They have allowed just 12.8 points per game and about 250 offensive yards per game to their opponents. The Bills have also had two shutouts this season.The toughest part of the Titans offense is the obvious run game with Derrick Henry. The Titans have a problem converting on third downs, so the Bills could have the advantage early on, stopping Tennessee from making any progress. The Tennessee Titans should get Julio Jones back after he has missed the last two games with a hamstring injury.Buffalo Bills vs. Tennessee TitansWhen: Monday, October 18, 2021, at 8:15 PM ESTWhere: Nissan Stadium, Nashville, TennesseeTennessee Titans@TitansDerrick Henry focused on what's ahead, and that's a tough Bills defense"Playing these guys is always tough." 📰 » bit.ly/30mscG56:04 AM · Oct 14, 202114012Derrick Henry focused on what's ahead, and that's a tough Bills defense"Playing these guys is always tough." 📰 » bit.ly/30mscG5Buffalo Bills vs. Tennessee Titans Betting OddsSpreadsBills: -6.0 (-105)Titans: +6.0 (-115)MoneylineBills: -250Titans: +210TotalsBills: o53.5 (-110)Titans: u53.5 (-110)Buffalo Bills@BuffaloBillsTitans Week is HERE!We’re LIVE with Coach McDermott before practice at One Bills Drive.#BUFvsTEN | #BillsMafia twitter.com/i/broadcasts/1…12:07 PM · Oct 14, 202115313Titans Week is HERE!We’re LIVE with Coach McDermott before practice at One Bills Drive.#BUFvsTEN | #BillsMafia twitter.com/i/broadcasts/1…Buffalo Bills vs. Tennessee Titans PicksThe Buffalo Bills and Tennessee Titans are usually better matched than they are heading into Monday night's game. The Buffalo Bills are playing like a team that has a chip on their shoulder and was just one game away from the Super Bowl last season. This season's matchup won't be as lopsided as the 2020 version, but the Bills will likely move the ball up and down the field with ease.Buffalo Bills vs. Tennessee Titans Key InjuriesBillsRB Taiwan Jones-hamstring (questionable)C Ryan Bates-ankle (questionable)LB Matt Milano-hamstring (questionable)LG Jon Feliciano-elbow (questionable)TitansLT Taylor Lewan -toe (questionable)OLB Bud Dupree-knee (questionable)RB Jeremy McNichols-ankle (questionable)WR A.J. Brown-hamstringWR Julio Jones-hamstringCB Kristian Fulton-hamstring (questionable)WR Nick Westbrook-Ikhine-hamstring (questionable)G Rodger Saffold-shoulder (questionable)Buffalo Bills vs. Tennessee Titans Head to HeadThis will be the fourth meeting in four years between the Buffalo Bills and Tennessee Titans. Last season, the game was played on a Tuesday due to a COVID-19 outbreak with the Titans. Tennessee put a stop to Buffalo's winning streak with a dominant 42-16 victory.Buffalo Bills vs. Tennessee Titans PredictionThe Buffalo Bills have been playing lights out the last few weeks. Josh Allen has been one of the best quarterbacks in the league, and the Titans defense just won't be able to stop that. The Bills' defense will also prove to be too much for the Titans' offense.PredictionThe Buffalo Bills will go 5-1 with a 37-28 win over the Tennessee Titans.