Barcelona were held to a 1-1 draw away to Napoli on Tuesday, extending their unimpressive winless run in Champions League knockout matches in Italy to six.
Quique Setien's men fell behind late in the first half to Dries Mertens' gorgeous 25-yard strike, seeing the Belgian go level with Marek Hamsik as the club's all-time leading scorer on 121.
Barca did rescue a draw that at least sees them return home with an away goal, and therefore an advantage, with Antoine Griezmann equalising despite an otherwise anonymous outing.
Still, Barca - who had Arturo Vidal sent off towards the end - remain winless away to Italian opposition in the knockout phase of the Champions League since a 1-0 victory at Milan in April 2006, when Napoli's incumbent coach Gennaro Gattuso was in the Rossoneri midfield.
Following Tuesday's stalemate, we look back at the other results in this run...
Inter 3-1 Barcelona, 2009-10 (semi-final first leg)
The good old days, when Jose Mourinho v Pep Guardiola was about as gripping as it got. Although the tie was billed as being pragmatism v flamboyance, it was the typically disciplined Inter who thrilled in a 3-1 first-leg win in San Siro. Pedro opened the scoring, but the hosts ultimately romped to victory through Wesley Sneijder, Maicon and Diego Milito. The Italians succumbed 1-0 in Barcelona after the dubious sending off of Thiago Motta, but they clung on to spark comically passionate celebrations from Mourinho and Inter went on to lift the trophy.
Milan 0-0 Barcelona, 2011-12 (quarter-final first leg)
Barca certainly couldn't be accused of failing to dominate in San Siro in 2012, as they controlled much of the game in Italy, but Messi and company failed to find a way through. Luca Antonini was crucial to that, making a brilliant last-ditch block late on to ensure Milan went to Camp Nou with a fighting chance. As it was, Barca had too much for them in the second leg, Messi scoring two penalties as they claimed a 3-1 win.
Milan 2-0 Barcelona, 2012-13 (last-16 first leg)
A major shock saw Barca seemingly staring at an early exit in 2012-13, with Sulley Muntari and Kevin-Prince Boateng scoring in a 2-0 win in San Siro. The Rossoneri had been forced to defend desperately at times, before stealing two goals in the second period. Thankfully for Barca it didn't prove costly, as they crushed Milan 4-0 in the return leg, with Messi's brace added to by David Villa and Jordi Alba. It made Barca the first team to overturn a two-goal first-leg deficit without scoring an away goal.
Juventus 3-0 Barcelona, 2016-17 (quarter-final first leg)
Massimiliano Allegri's Juve became 'nearly men' in the Champions League, but there was also no doubting their class, as the 3-0 win over Barca in April 2017 showed. It was a commanding display in Turin, with two-goal Paulo Dybala turning on the style. Giorgio Chiellini rounded off the win that rarely looked like being overturned in Barcelona despite drawing inspiration from their comeback against Paris Saint-Germain in the previous round. Juve held out for a 0-0 draw.
Roma 3-0 Barcelona, 2017-18 (quarter-final second leg)
Barca have been involved in some monumental Champions League comebacks and turnarounds in recent years – on this occasion they were the victims. After winning 4-1 at Camp Nou, needing some luck to do so as they produced an unimpressive display, Barca looked destined for the semi-finals, but in Rome they were completely outmanoeuvred by an energetic Roma. Goals from Edin Dzeko and Daniele De Rossi left Barca twitching ahead of the latter stages and Kostas Manolas' header eight minutes from time secured a famous result, dumping Barca out of the competition.