On March 1, 2008, the Pride World Welterweight Championship was unified with the UFC Middleweight Title on March 1, 2008, when Anderson Silva defeated Dan Henderson at UFC 82.
The Middleweight Title has been held by the likes of Dave Menne, Rich Franklin, and at UFC 64, Anderson Silva won the title. Silva defended his title against the likes of Nate Marquardt, Rich Franklin, Dan Henderson, Patrick Cote, Thales Leites, Demian Maia, Chael Sonnen, Vitor Belfort and Yushin Okami, while holding onto the belt for a total of 2,457 days, a record for the longest title reign in UFC history. At UFC 162, Chris Weidman defeated Silva to win the Middleweight Title. Weidman's reign came to an end when he was beaten by Luke Rockhold at UFC 194.
At UFC 199, Michael Bisping won the Middleweight Title and eventually lost it to the returning GSP at UFC 217. As GSP vacated the title due to complications with ulcerative coltis, on December 7, 2017, Robert Whittaker was promoted as the Middleweight Champion, having won the Interim Title at UFC 213.
At UFC 243, the interim Middleweight Champion Israel Adesanya defeated Robert Whittaker to win the undisputed UFC Middleweight Championship.
The current champion Adesanya, defended his title against Yoel Romero and Paulo Costa at UFC 248 and UFC 253 respectively.