Offensive Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Quarterback | Kyler Murray | Trace McSorley | Colt McCoy |
| Running Back | James Conner | Darrel Williams | Eno Benjamin Jonathan Ward Keaontay Ingram |
| Wide Receiver | Marquise Brown | A.J. Green | |
| Tight End | Zach Ertz | Stephen Anderson | Maxx Williams Trey McBride |
| Left Tackle | D.J. Humphries | Josh Jones | — |
| Left Guard | Justin Pugh | Max Garcia | — |
| Center | Rodney Hudson | Sean Harlow | — |
| Right Guard | Will Hernandez | Lecitus Smith | — |
| Right Tackle | Kelvin Beachum | — | — |
Defensive Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Left Defensive End | J.J. Watt | Michael Dogbe | — |
| Nose Tackle | Rashard Lawrence | Leki Fotu | — |
| Right Defensive End | Zach Allen | Jonathan Ledbetter | — |
| Left Inside Linebacker | Zaven Collins | Nick Vigil | Ben Niemann |
| Right Inside Linebacker | Isaiah Simmons | Tanner Vallejo | Zeke Turner |
| Strongside Linebacker | Markus Golden | Devon Kennard | Cameron Thomas |
| Weakside Linebacker | Dennis Gardeck | Victor Dimukeje | Myjai Sanders |
| Right Cornerback | Marco Wilson | Christian Matthew | Antonio Hamilton |
| Left Cornerback | Byron Murphy | Trayvon Mullen | — |
| Strong Safety | Jalen Thompson | Deionte Thompson | — |
| Free Safety | Budda Baker | Charles Washington | — |
Special Teams Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Punter | Andy Lee | — | — |
| Kicker | Matt Prater | — | — |
| Long Snapper | Aaron Brewer | — | — |
| Holder | Andy Lee | — | — |
| Punt Returner | Greg Dortch | Rondale Moore | — |
| Kick Returner | Eno Benjamin | Jonathan Ward | — |
