Offensive Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Quarterback | Jalen Hurts | Gardner Minshew | Ian Book |
| Running Back | Miles Sanders | Kenneth Gainwell | Boston Scott Trey Sermon |
| Wide Receiver | A.J. Brown | DeVonta Smith | Quez Watkins Zach Pascal Britain Covey |
| Tight End | Dallas Goedert | Jack Stoll | Grant Calcaterra Tyree Jackson |
| Left Tackle | Jordan Mailata | Andre Dillard | — |
| Left Guard | Landon Dickerson | Sua Opeta | Josh Sills |
| Center | Jason Kelce | Cam Jurgens | — |
| Right Guard | Isaac Seumalo | Josh Sills | — |
| Right Tackle | Lane Johnson | Jack Driscoll | — |
Defensive Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Left Defensive End | Brandon Graham | Janarius Robinson | — |
| Right Defensive End | Josh Sweat | Robert Quinn | Derek Barnett |
| Left Defensive Tackle | Fletcher Cox | Marvin Wilson | Jordan Davis |
| Right Defensive Tackle | Javon Hargrave | Marlon Tuipulotu | Milton Williams |
| Strongside Linebacker | Haason Reddick | Patrick Johnson | Kyron Johnson |
| Middle Linebacker | T.J. Edwards | Nakobe Dean | — |
| Weakside Linebacker | Kyzir White | Shaun Bradley | — |
| Right Cornerback | Darius Slay | Zech McPhearson | Josh Jobe |
| Left Cornerback | James Bradberry | Avonte Maddox | Josiah Scott |
| Strong Safety | Marcus Epps | Reed Blankenship | — |
| Free Safety | Chauncey Gardner-Johnson | K'Von Wallace | — |
Special Teams Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Punter | Arryn Siposs | — | — |
| Kicker | Jake Elliott | — | — |
| Long Snapper | Rick Lovato | — | — |
| Holder | Arryn Siposs | — | — |
| Punt Returner | Britain Covey | Quez Watkins | Kenneth Gainwell |
| Kick Returner | Britain Covey | Quez Watkins | Kenneth Gainwell |
