| Date | Match | Time (ET) |
| October 25, 2018 | Miami Dolphins vs Houston Texans | 8:20 PM |
| October 28, 2018 | Philadelphia Eagles vs Jacksonville Jaguars | 9:30 AM |
| October 28, 2018 | Baltimore Ravens vs Carolina Panthers | 1:00 PM |
| October 28, 2018 | New York Jets vs Chicago Bears | 1:00 PM |
| October 28, 2018 | Tampa Bay Buccaneers vs Cincinnati Bengals | 1:00 PM |
| October 28, 2018 | Seattle Seahawks vs Detroit Lions | 1:00 PM |
| October 28, 2018 | Denver Broncos vs Kansas City Chiefs | 1:00 PM |
| October 28, 2018 | Washington Redskins vs New York Giants | 1:00 PM |
| October 28, 2018 | Cleveland Browns vs Pittsburgh Steelers | 1:00 PM |
| October 28, 2018 | Indianapolis Colts vs Oakland Raiders | 4:05 PM |
| October 28, 2018 | San Francisco 49ers vs Arizona Cardinals | 4:25 PM |
| October 28, 2018 | Green Bay Packers vs Los Angeles Rams | 4:25 PM |
| October 28, 2018 | New Orleans Saints vs Minnesota Vikings | 8:20 PM |
| October 29, 2018 | New England Patriots vs Buffalo Bills | 8:15 PM |
