Offensive Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Quarterback | Matthew Stafford | John Wolford | Bryce Perkins |
| Running Back | Darrell Henderson Jr. | Malcolm Brown | Cam AkersKyren Williams |
| Wide Receiver | Cooper Kupp | Allen Robinson | Van JeffersonBen SkowronekBrandon PowellTutu AtwellLance McCutcheon |
| Tight End | Tyler Higbee | Brycen Hopkins | Kendall Blanton |
| Left Tackle | Alaric Jackson | Ty Nsekhe | — |
| Left Guard | Oday Aboushi | — | — |
| Center | Brian Allen | Matt Skura | — |
| Right Guard | Bobby Evans | — | — |
| Right Tackle | Rob Havenstein | — | — |
Defensive Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Left Defensive End | A'Shawn Robinson | Marquise Copeland | — |
| Nose Tackle | Greg Gaines | Jonah Williams | Bobby Brown III |
| Right Defensive End | Aaron Donald | Mike Hoecht | — |
| Left Inside Linebacker | Ernest Jones | Jake Hummel | Travin Howard |
| Right Inside Linebacker | Bobby Wagner | Christian Rozeboom | Jake Gervase |
| Strongside Linebacker | Justin Hollins | Terrell Lewis | — |
| Weakside Linebacker | Leonard Floyd | Daniel Hardy | — |
| Right Cornerback | Jalen Ramsey | Derion Kendrick | Decobie DurantGrant Haley |
| Left Cornerback | Troy Hill | David Long | Robert RochellShaun Jolly |
| Strong Safety | Taylor Rapp | Russ Yeast | Jordan Fuller |
| Free Safety | Nick Scott | Terrell Burgess | Quentin Lake |
Special Teams Positions
| POSITION | STARTER | SECOND | THIRD+ |
| Punter | Riley Dixon | — | — |
| Kicker | Matt Gay | — | — |
| Holder | Riley Dixon | — | — |
| Punt Returner | Brandon Powell | Cooper Kupp | — |
| Kick Returner | Brandon Powell | Kyren Williams | — |
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