| Date | Match | Time (ET) |
| November 22, 2018 | Chicago Bears vs Detroit Lions | 12:30 PM |
| November 22, 2018 | Washington Redskins vs Dallas Cowboys | 4:30 PM |
| November 22, 2018 | Atlanta Falcons vs New Orleans Saints | 8:20 PM |
| November 25, 2018 | Oakland Raiders vs Baltimore Ravens | 1:00 PM |
| November 25, 2018 | Jacksonville Jaguars vs Buffalo Bills | 1:00 PM |
| November 25, 2018 | Seattle Seahawks vs Carolina Panthers | 1:00 PM |
| November 25, 2018 | Cleveland Browns vs Cincinnati Bengals | 1:00 PM |
| November 25, 2018 | Miami Dolphins vs Indianapolis Colts | 1:00 PM |
| November 25, 2018 | New England Patriots vs New York Jets | 1:00 PM |
| November 25, 2018 | New York Giants vs Philadelphia Eagles | 1:00 PM |
| November 25, 2018 | San Francisco 49ers vs Tampa Bay Buccaneers | 1:00 PM |
| November 25, 2018 | Arizona Cardinals vs Los Angeles Chargers | 4:05 PM |
| November 25, 2018 | Pittsburgh Steelers vs Denver Broncos | 4:25 PM |
| November 25, 2018 | Green Bay Packers vs Minnesota Vikings | 8:20 PM |
| November 26, 2018 | Tennessee Titans vs Houston Texans | 8:15 PM |
