Wednesday, September 21, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Jordan Matthews | TE | Wed, Sep 21 | Knee - ACL | IR. Injured Reserve |
Monday, September 19, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Tyler Kroft | TE | Mon, Sep 19 | Knee - MCL | Out for Week 3 at Denver. Expected Return - Week 6 |
| George Kittle | TE | Mon, Sep 19 | Groin | Questionable for Week 3 at Denver |
| Daniel Brunskill | OT | Mon, Sep 19 | Hamstring | Questionable for Week 3 at Denver |
| Tyrion Davis-Price | RB | Mon, Sep 19 | Ankle | Out for Week 3 at Denver. Expected Return - Week 6 |
Sunday, September 18, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Trey Lance | QB | Sun, Sep 18 | Ankle | Out for Week 3 at Denver |
Friday, September 16, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Maurice Hurst | DT | Fri, Sep 16 | Biceps | IR. Injured Reserve | - |
| Curtis Robinson | LB | Fri, Sep 16 | Ankle | IR. Injured Reserve | Week 5 |
Wednesday, September 14, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Jason Verrett | DB | Wed, Sep 14 | Knee - ACL | Physically Unable to Perform | Week 5 |
| Jordan Willis | DE | Wed, Sep 14 | Undisclosed | IR. Injured Reserve | Week 6 |
| Elijah Mitchell | RB | Wed, Sep 14 | Knee - MCL | IR. Injured Reserve | Week 10 |
Tuesday, September 13, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Elijah Mitchell | RB | Tue, Sep 13 | Knee - MCL | IR. Injured Reserve. | WEEK 10 |
| Jordan Matthews | TE | Tue, Sep 13 | Knee - ACL | IR. Injured Reserve | - |
Monday, September 12, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| George Kittle | TE | Mon, Sep 12 | Groin | Questionable for Week 2 vs. Seattle |
| Daniel Brunskill | OT | Mon, Sep 12 | Hamstring | Questionable for Week 2 vs. Seattle |
Sunday, September 11, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS |
| Maurice Hurst | DT | Sun, Sep 11 | Biceps | IR. Injured Reserve |
Monday, September 5, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Curtis Robinson | LB | Mon, Sep 5 | Ankle | IR. Injured Reserve. | Week 5 |
Thursday, September 1, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Jimmie Ward | CB | Thu, Sep 1 | Hamstring | IR. Injured Reserve. | Week 5 |
| Kalia Davis | DT | Thu, Sep 1 | Undisclosed | NFI-R for Week 2 vs. Seattle | - |
Sunday, August 28, 2022
| PLAYER | POSITION | UPDATED | INJURY | INJURY STATUS | EXPECTED RETURN |
| Jason Verrett | DB | Sun, Aug 28 | Knee - ACL | Physically Unable to Perform. | Week 5 |
